4D computed tomography and lung function imaging in small animals

Over the last five years the Laboratory for Dynamic Imaging team has developed
world-leading X-ray imaging and computed tomography technology for the measurement of the patterns of regional lung function. This development represents a major breakthrough in the study of lung disease, as we are the first and only team with the capability to measure
structural and regional lung function throughout the respiratory cycle. This technology combines phase contrast X-ray imaging, which uses X-rays from a semi-coherent radiation source, and our unique variant of the engineering technology of velocimetry. Detailed measurement of motion allows the calculation of high-resolution regional maps of airflow as well as lung resistance and compliance at each stage of a breath. We can uniquely obtain pulmonary function measures (normally measured at the mouth and averaged over the entire lung) at every location within the lung. This collection contains tomography, tissue motion, and lung function images from a variety of experiments with small animals under a number of pathological conditions and breathing states, including asthma, neonatal ventilation,cystic fibrosis, congenital diaphragmatic hernia, and emphysema. This unique information can improve understanding of lung disease, potentially leading to novel diagnostic and therapeutic technologies.