Resource of genetics and epigenetics data for elucidating the underlying mechanisms of cancer predisposition and progression

PEDIGREE (Pathology, Epidemiology, DNA, Informatics & Genetics: a Research Enabling Enterprise) is a resource of 100,000 people, 20,000 cancer families, 1,000,000 bio-specimens, data, researchers and community representatives established to conduct collaborative research on cancer. It provides a research platform for studying the genetic and environmental causes of some of the common cancers that affect Australians with significant focus on breast, prostate, and colorectal cancer, using novel population-based family designs, complemented by multiple-case families ascertained through clinics and/or the community.These studies involve numerous national and international multidisciplinary collaborations. Close interaction with clinical colleagues actively contributes to the translation of new genetic information to improve personal cancer risk assessment and more generally, health outcomes for all Australians.