Systems Pharmacology of Antimicrobial Resistance

The world is facing an enormous and growing threat from the emergence of bacterial ‘superbugs’ Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae that are resistant to all antibiotics, while no novel antibiotics are in current drug discovery pipeline. As described in the ‘Bad Bugs, No Drugs’ paper published by the Infectious Diseases Society of America, “as antibiotic discovery stagnates, a public health crisis brews”. This project will employ systems pharmacology approaches to develop bioinformatics databases and tools to respond to the recent global call for discovery of new antibiotics. This collection will contain data that is part of a large project headed by the Monash Institute of Pharmaceutical Sciences’s Professor Jian Li.

There are currently no services in the world that host antibiotic combination databases. This collection of data has the potential to be widely used by many research communities worldwide who are interested in antibiotic resistance and understanding its underlying molecular mechanisms. This data will be released publicly and accessible in a web application.